Peptide Cheat Sheet: Every Major Compound, Status & Evidence at a Glance
- Written by
- Daniel Reyes, PhD
- Medically reviewed by
- Dr. Sarah Lindqvist, MD
- Published
- June 20, 2025
- Updated
- June 20, 2025
- Last medical review
- June 20, 2025
- Reviewer scope
- Metabolic health
A useful peptide cheat sheet answers four questions per compound: is it FDA-approved, how strong is the human evidence, what endpoints were actually studied, and what are the known risks. This reference covers BPC-157, TB-500, CJC-1295, Ipamorelin, GHK-Cu, AOD-9604, MK-677, and semaglutide — with each claim linked to a full, cited guide.
How to read this cheat sheet
Compounds are listed with regulatory status first, because that single fact changes everything downstream: quality control, legal exposure, and how much the evidence can be trusted. Evidence grades follow our editorial policy: Strong, Moderate, Early clinical, Preclinical-dominant, or Mixed.
The quick-reference table
- BPC-157 — Not FDA-approved; FDA compounding-risk list. Evidence: preclinical-dominant (rodent tendon/gut models). Key risk: no human safety dataset.
- TB-500 — Not FDA-approved; WADA-prohibited. Evidence: preclinical-dominant. Key risk: no human trials of the sold fragment.
- CJC-1295 (DAC) — Not FDA-approved; FDA safety-flagged. Evidence: phase-I pharmacology only. Key risk: multi-day non-pulsatile GH elevation.
- Ipamorelin — Not FDA-approved. Evidence: early clinical; phase-II program failed. Key risk: unknown long-term GH-axis effects.
- GHK-Cu — Cosmetic topical use common; injectable not approved. Evidence: mixed by route. Key risk: route conflation.
- AOD-9604 — Not FDA-approved. Evidence: early clinical; obesity program discontinued. Key risk: efficacy never confirmed.
- MK-677 (ibutamoren) — Not FDA-approved; oral, not a peptide. Evidence: multiple RCTs with mixed outcomes. Key risks: appetite, glucose, edema.
- Semaglutide — FDA-approved for defined indications, prescription-only. Evidence: strong. Key risk: compounded versions are a separate, FDA-warned category.
Each row above compresses a full evidence file. Start with our BPC-157 dosage research review and the TB-500 fragment breakdown, see how CJC-1295 with DAC earned its safety flag, then contrast everything with semaglutide — the one compound here with real trials — and the MK-677 trade-off file.
What no cheat sheet can give you
A dose. Study parameters vary wildly by model, route, and population, and none of the unapproved compounds above has an established human dose. Our reconstitution calculator will do the arithmetic for a clinician-prescribed dose, but the prescription itself must come from a licensed provider.
Frequently asked questions
Which peptides are FDA-approved?
What do the evidence grades on this cheat sheet mean?
Is there a safe dose for research peptides?
Where can I compare these compounds side by side?
Questions to ask a licensed clinician
- Which of these compounds, if any, has evidence relevant to my actual goal?
- What FDA-approved alternatives should be considered first?
References
- US Food and Drug Administration (2023). Certain bulk drug substances for use in compounding that may present significant safety risks. FDA Human Drug Compounding. SourceAgency notice
- World Anti-Doping Agency (2024). The Prohibited List — S2 peptide hormones, growth factors and related substances. WADA. SourceAgency list
- Wilding JPH, Batterham RL, Calanna S, et al. (2021). Once-weekly semaglutide in adults with overweight or obesity (STEP 1). New England Journal of Medicine. SourcePhase-III RCT
Related tools
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