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PeptidesEvidence: Mixed

Peptide Cheat Sheet: Every Major Compound, Status & Evidence at a Glance

Medically reviewed by
Dr. Sarah Lindqvist, MD
Published
June 20, 2025
Updated
June 20, 2025
Last medical review
June 20, 2025
Reviewer scope
Metabolic health
Gloved researcher handling a peptide vial in a dark laboratory, representing the compounds on this cheat sheet ranked by evidence

A useful peptide cheat sheet answers four questions per compound: is it FDA-approved, how strong is the human evidence, what endpoints were actually studied, and what are the known risks. This reference covers BPC-157, TB-500, CJC-1295, Ipamorelin, GHK-Cu, AOD-9604, MK-677, and semaglutide — with each claim linked to a full, cited guide.

How to read this cheat sheet

Compounds are listed with regulatory status first, because that single fact changes everything downstream: quality control, legal exposure, and how much the evidence can be trusted. Evidence grades follow our editorial policy: Strong, Moderate, Early clinical, Preclinical-dominant, or Mixed.

Pipette and test tubes in a dark research lab, illustrating how evidence grades are assigned to each peptide compound in the cheat sheet

The quick-reference table

  • BPC-157 — Not FDA-approved; FDA compounding-risk list. Evidence: preclinical-dominant (rodent tendon/gut models). Key risk: no human safety dataset.
  • TB-500 — Not FDA-approved; WADA-prohibited. Evidence: preclinical-dominant. Key risk: no human trials of the sold fragment.
  • CJC-1295 (DAC) — Not FDA-approved; FDA safety-flagged. Evidence: phase-I pharmacology only. Key risk: multi-day non-pulsatile GH elevation.
  • Ipamorelin — Not FDA-approved. Evidence: early clinical; phase-II program failed. Key risk: unknown long-term GH-axis effects.
  • GHK-Cu — Cosmetic topical use common; injectable not approved. Evidence: mixed by route. Key risk: route conflation.
  • AOD-9604 — Not FDA-approved. Evidence: early clinical; obesity program discontinued. Key risk: efficacy never confirmed.
  • MK-677 (ibutamoren) — Not FDA-approved; oral, not a peptide. Evidence: multiple RCTs with mixed outcomes. Key risks: appetite, glucose, edema.
  • Semaglutide — FDA-approved for defined indications, prescription-only. Evidence: strong. Key risk: compounded versions are a separate, FDA-warned category.

Each row above compresses a full evidence file. Start with our BPC-157 dosage research review and the TB-500 fragment breakdown, see how CJC-1295 with DAC earned its safety flag, then contrast everything with semaglutide — the one compound here with real trials — and the MK-677 trade-off file.

What no cheat sheet can give you

A dose. Study parameters vary wildly by model, route, and population, and none of the unapproved compounds above has an established human dose. Our reconstitution calculator will do the arithmetic for a clinician-prescribed dose, but the prescription itself must come from a licensed provider.

Frequently asked questions

Which peptides are FDA-approved?
Of the compounds on this cheat sheet, only semaglutide holds FDA approval, for defined diabetes and weight-management indications by prescription. BPC-157, TB-500, CJC-1295, ipamorelin, injectable GHK-Cu, AOD-9604, and MK-677 are all unapproved, and several appear on the FDA list of compounding substances with significant safety risks.
What do the evidence grades on this cheat sheet mean?
Grades follow our editorial policy: Strong means large randomized human trials; Moderate means real but limited human RCT data; Early clinical means human trials that stalled or failed; Preclinical-dominant means the evidence is mostly animal studies; Mixed means the grade depends on route or formulation.
Is there a safe dose for research peptides?
No. None of the unapproved compounds here has an established human dose from adequately powered trials, so any number you see online is extrapolation or tradition. Dosing is a clinical decision for a licensed prescriber — this site reports what studies used and never recommends doses.
Where can I compare these compounds side by side?
Our interactive peptide comparison table shows FDA status, evidence grade, studied endpoints, and key risks in one view, and each row links to a fully cited guide with the primary sources listed after every claim.

Questions to ask a licensed clinician

  • Which of these compounds, if any, has evidence relevant to my actual goal?
  • What FDA-approved alternatives should be considered first?

References

  1. US Food and Drug Administration (2023). Certain bulk drug substances for use in compounding that may present significant safety risks. FDA Human Drug Compounding. SourceAgency notice
  2. World Anti-Doping Agency (2024). The Prohibited List — S2 peptide hormones, growth factors and related substances. WADA. SourceAgency list
  3. Wilding JPH, Batterham RL, Calanna S, et al. (2021). Once-weekly semaglutide in adults with overweight or obesity (STEP 1). New England Journal of Medicine. SourcePhase-III RCT

Something incorrect in this guide? Report a correction. Material corrections are noted on the page with the date and nature of the change.